Gastric cancer targeted therapy
Gastrointestinal stromal tumors: review on morphology, diagnosis and management Emoke Fulop, Simona Marcu, Doina Milutin, Angela Borda Gastrointestinal stromal tumors GISTs are the most frequent mesenchymal tumors of the gastrointestinal tract.
Major advances in their definition and classification and the understanding of their molecular mechanisms have recently been made.
Gastric cancer targeted therapy
These advances have become a model of targeted therapy in oncology. The differential diagnosis of GISTs includes the other mesenchymal tumors of the gastrointestinal tract, such gastric cancer targeted therapy leiomyomas, leiomyosarcomas, schwannomas and intra-abdominal fibromatosis.
The evaluation of the prognosis is essential and is based on a simple algorithm using two histoprognostic parameters, tumor size and mitotic index. The treatment of localized GISTs is surgical resection and that of advanced or unresecable GISTs is based on the use of targeted therapy, imatinib, which is a pharmacological antagonist of the c-kit protein. Proper understanding and utilization of the diagnostic criteria and classification of GISTs by pathologists are essential for good patient management.
Histopathological changes in acute ischemic stroke Otilia Margaritescu, L. Mogoanta, Ionica Pirici, D. Pirici, Daniela Cernea, Cl.
Margaritescu We study here the histopathological changes in twenty-two cases of acute ischemic stroke. The average age of the patients was year-old, and the interval from the onset of the disease to the death varied from 6 hours to 15 years. The brain lesions after acute stroke were observed in all regions. Their evolution allowed us to classify them in fourth stages. In the third phase 26 days years after the onsetwe included six cases characterized by the absence of an inflammatory reaction, presence of cavitation, astrogliosis and macrophages.
Gastric cancer targeted therapy.
Our study describes the heterogeneity of brain injury after acute ischemic stroke with the participation of all brain components, and the chronology in which these lesions develop and evolve.
Analysis of the immunohistochemical expression of mammaglobin A in primary breast carcinoma and lymph node metastasis M. Few data are available about the immunohistochemical expression of this marker in mammary carcinoma and about the significance of the positive reaction.
Our purpose was to investigate the sensitivity of the mammaglobin expression in breast cancer and to determine its correlations with conventional prognostic parameters.
There were investigated 47 patients with breast carcinoma, and slides from paraffin blocks were stained with an antibody against mammaglobin.
The immunohistochemical reaction was scored based on the gastric cancer targeted therapy of positive tumor cells in both primary tumors and lymph node metastasis. Positive reaction for gastric cancer targeted therapy was found in the normal mammary tissue adjacent to the tumor in all cases, in A significant correlation was found between the mammaglobin expression in the primary tumor, grade, and lymph node status, but not with the age of the patient, pathologic subtype of carcinoma and stage of the tumor.
The ductal in situ carcinoma associated to the invasive tumor did not influence significantly the prognostic value of mammaglobin expression. Out results suggest that mammaglobin is a sensitive marker of breast carcinoma, it defines a subgroup of patients with better prognosis and is a useful method to detect breast cancer metastases. Effects of 60Co gamma-rays on human osteoprogenitor cells C.
Tomuleasa, V. Postescu, Gabriela Chereches, Otilia Barbos, Corina Tatomir Background: Radiation therapy is one of the most efficient treatments of neoplastic diseases used worldwide. However, patients who undergo radiotherapy may develop side effects that can be life threatening because tissue complications caused by radiation-induced stem cell depletion may result in structural and functional alterations of the surrounding matrix.
This treatment also damages the osteogenic activity of human bone marrow by suppressing osteoblasts, leading to post-irradiation sequelae. Even if widely used in oncology, there is still little information on the fate and potential therapeutic efficacy of electromagnetic rays. Material and Methods: We addressed this question using both human mesenchymal stem cells and osteoblasts.
The technique of anti-alkaline phosphatase FITC-staining demonstrated the presence of this specific ectoenzyme.
Gastric cancer treatment algorithm - Gastric cancer targeted therapy
The viability of irradiated cells was assessed using Trypan Blue staining. The comparison between cell lineages after culture in osteogenic media regarding phenotypical characterization and the intensity of the mineralization process gastric cancer targeted therapy histology stainings Alizarin Red S, Alcian Blue and von Kossaand the MTT-based proliferation assay. Results: After irradiation, the proliferation and differentiation of osteoprogenitor cells is dose-dependent.
Conclusions: This study is one among the first papers investigating the gastric cancer targeted therapy of low-dose gamma-irradiation on stem cell culture, focusing on the potential applications in radiation oncology and various palliative treatments. Corresponding author: Olga Soritau, MD, e-mail: osoritau hotmail. Ceausu, Cristina Tanase, Ruxandra Stanculescu, Teodora Vladescu, Zenaida Antihelmintic copii Carcinoma of the uterine cervix is the most frequent malignancy in women, with an incidence of approximately Twenty-six archived formalin-fixed paraffin-embedded samples of squamous cell carcinoma, selected from 30 Papanicolaou-positive smears, have been analyzed using standard HE stain and the IHC indirect tristadial ABC peroxidase method for four antibodies: p53, p63, Ki, HPV.
Statistical analysis has been done using the Student t-test, helmintox thuoc two tails, "paired two samples for mean" variant. Two thirds of the cases were medium and poor differentiated gastric cancer targeted therapy. The expression pattern of the proliferation and prognostic factors was biologically correlated with the histopathological type and HPV-infection.
Immunohistochemical and transmission electron microscopy study regarding myofibroblasts in fibroinflammatory epulis and giant cell peripheral granuloma Ana Maria Filioreanu, Eugenia Popescu, C. Cotrutz, Carmen Elena Cotrutz Fibroblasts represent the main cellular population in the connective tissue; they have a central role in extracellular semne infectate de vierme ECM synthesis, degradation and remodeling.
These cells may express a substantial heterogeneity regarding their morphology and functions in pathological conditions and during tissue remodeling. Myofibroblasts are a good example for heterogeneity and phenotypical changes.
These cells can be morphologically and immunologically defined by the expression of specific cytoskeleton proteins. Myofibroblasts show cytoplasmic actin microfilaments organized as stress fibers and interconnected by gap or adherens junctions. These cells come also in contact with extracellular matrix by focal contacts. Myofibroblasts play fundamental roles in pathologic conditions, even by activation and proliferation or by deletion.
Moreover, these cells seem to be involved in formation and repair of the ECM compounds, proliferation and differentiation of the epithelial, vascular or neurogenic elements. The purpose of the present study is to emphasize the presence and distribution of myofibroblasts in the reactive stromal tissue of granulation tumors in the oral area, fibroinflammatory epulis and giant cells peripheral granuloma, by means of immunocytochemical and transmission electron microscopy studies.
Both tumor types shown a common characteristic of the presence of reactive inflammatory stromal tissue and myofibroblasts are a common issue.
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Goldis, C. Vernic Purpose: The purpose of this study was to identify the clinicopathological factors that influence the prognosis of patients having undergone surgery for gastric cancer. Material and Methods: From the total number of patients men and 79 women diagnosed with gastric cancer in the period61 operated patients were selected. On this group, we performed a prospective study regarding the evolution and aggressiveness of gastric cancer, on a duration of 5 years.
Survival time was calculated from the month of the surgical intervention until the month of death or confirmation of survival, and survival rate was represented by the percentage of survivals at the end of the observed interval in years and months.
According to the maximum level of tumor invasion we identified: pTis - one case 1.
We identified 43 gastric carcinomas with metastases in regional lymph nodes According to the number of lymph nodes involved: pN0 - 18 cases From the total of carcinomas, stage IV consisted of the greatest number of tumors, representing We generally remarked the increase of the number of cases in advanced stages.
Conclusions: In the studied group, we noted a great number of gastric carcinomas diagnosed in stages T3 and T4 Cardial tumor locations and gastric stump locations, as well as "signet-ring" cell and undifferentiated carcinomas prove to be aggressive, being diagnosed in advanced stages. We noted a significant correlation between the degree of tumor gastric cancer targeted therapy and the level of invasion, as well as the presence of distance and lymph node metastases.
Survival at 5 years of patients included in the study was correlated significantly with the level of tumor invasion, the presence of lymph node and distance metastases, and the TNM stage. Fractal analysis of astrocytes in stroke and dementia D. Pirici, L. Subjective differences can be described between these pathologies in what it concerns astrocyte implication, but these have not been yet subjected to a morphometrical quantification.
Here we apply a fractal dimension FD analysis algorithm to differentiate both between fibrous, protoplasmatic and activated astroglia; but also between the three pathological conditions studied. Analyzing more than astroglia, we show here first that FD can clearly differentiate between the three morphological subtypes. Second, we describe resemblances of the FD values for ischemic and hemorrhagic lesions, and significant differences when these are compared to AD patients.
These results are further discussed and integrated in what it regards the preferential regions proved to be affected in these conditions, and which parallels our results. This work illustrates that fractal dimension analysis of astroglia is a useful method for quantitatively describing gliosis in different pathologies, and that it may offer more insight into the pathogenesis of brain diseases.
Alveolar bone dehiscences and fenestrations: an anatomical study and review Vanda Roxana Nimigean, V. Cergan, Simona Moraru Aim: To determine the prevalence and distribution of fenestrations and dehiscences of the jaw bones among the Caucasian population, to find if any correlations can be established between their occurrence and certain teeth characteristics and to discuss the clinical implications the defects of alveolar process could have. Material and Methods: gastric cancer targeted therapy of specimens ranging from 21 to 54 years of age, having either complete dentition or reduced number of missing teeth were studied.
Teeth found to have one of the two defects were examined for signs of faceting attrition that was considered an indicative for excessive occlusal forces and were submitted except for the case of the third molars to an analysis concerning their bucco-lingual inclination in the jaw. Results: High-prevalence rates for both osseous entities were found. Fenestrations were present in More fenestrations were found in the maxilla: cauterizarea negului plantar No correlations could be established between the presence of dehiscences and fenestrations and the development of high-occlusal forces, whereas all teeth affected either by dehiscences or by fenestrations were found to have modifications of the normal bucco-lingual inclination angle's values p Corresponding author: Vanda Roxana Nimigean, DMD, DDS, PhD, e-mail: vandanimigean yahoo.
Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases Emoke Horvath, T. Mezei, Z. Pavai, M.
Jung The aim of this study is to present the diagnostic and differential diagnostic criteria of the bone marrow specimen involved by lymphomas based on the histomorphological platyhelminthes turbellaria features and clonality of the tumor cells, patterns of lymphoproliferation and diagnostic pitfalls. BMB material obtained from the right posterior iliac crest was represented from 87 untreated and treated patients with BM involving malignant lymphoma, stained with Hematoxylin-Eosin, Giemsa, Periodic Acid Schiff and Gomori's Silver.
Gastric cancer targeted therapy order to perform immunohistochemistry examination we used a large antibody panel. B-cell clonality was determined in six cases. We found eight reactive lymphoproliferative responses and 79 lymphoid neoplasms of which 45 were diagnosed as de novo lymphoma, the rest of 34 samples being examined for staging.
In eight cases, we found reactive lymphoid aggregates. The B-cell clonality test showed four monoclonal, one oligoclonal and one polyclonal diseases form.
Gastric cancer molecular subtypes
Diagnosis of lymphoma versus reactive aggregate has been based on the combination of a lot of antibodies and involvement pattern. Although investigation of gene rearrangement was necessary for the establishment of the correct diagnosis in only 6.
Steatosis is frequently observed in CHC and seems to have a significant impact on the natural history of the disease with respect to development of fibrosis.
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The aim of this study was to investigate the relationship between systemic parameters of oxidative stress, insulin resistance, steatosis degree, and fibrosis in CHC. Fifty patients with chronic hepatitis C 29 men and 21 women with the average age 45 yearswith or without steatosis, were tested for: oxidative stress and antioxidant status by measuring serum malondialdehyde MDAtotal blood non-proteic thiols concentration GSHgamma glutamyl transpeptidase GGT activity, lipid parameters, and liver function tests.
Hepatic steatosis was associated with an increase of MDA, correlated with its severity, and secondary with a decrease of GSH. The activity of serum GGT was net superior, in patients with steatosis, proportional with its degree. Conclusions: In patients infected by HCV genotype 1, oxidative stress and insulin resistance contribute to steatosis, which in turn exacerbates both insulin resistance and oxidative stress and accelerates the progression of fibrosis.
The induction of GGT is an adaptive response against oxidative damage elicited by lipid peroxidation and it may be critical in the progression of the disease. Tumor biomarkers in cervical cancer: focus on Ki proliferation factor and E-cadherin expression E. Anton, E.
Carasevici, Rodica Chirieac Despite recent advances in the immune mechanisms of cervical cancer CC and complex fecale ale copilului după tratamentul viermilor opportunities, relapse remains still an actual issue.
While predictive factors are required, current research is directed towards proliferation and tumor aggressiveness biomarkers as potential negative factors in CC. The main objectives were to assess tumor proliferation and invasiveness biomarkers Ki, E-cadherin and to identify potential correlation between biomarkers and classic prognostic factors in CC.
Radical hysterectomy specimens from 61 consecutive CC were immunohistochemically investigated for Ki and E-cadherin. Statistical analysis was performed in SPSS software, p 0. BRCA1 expression in invasive breast carcinomas and clinicopathological correlations Maria Comanescu, Carmen Florina Popescu BRCA1-positive tumors characterize a heterogeneous group of breast cancers with a specific range of histopathological and immuno-histochemical features.
We evaluated the relationship between morphological characteristics and immunohistochemical profile of 14 BRCA1-positive breast tumors from an initial study group of 40 breast tumors. All patients were females with an average age of Fourteen out of the 40 tumors were BRCA1-positive. All breast carcinomas in this study gastric cancer targeted therapy invasive.
The most common histological type in our study was invasive ductal carcinoma. The majority of the tumors were high-grade G3. The examination of the lymph node found metastasis in eight cases. We observed a high-celullar proliferation index in all cases.
The immunohistochemical study of BRCA1-protein is important to the study of the development and progression of the disease. Fahr's syndrome: diagnosis issues in patients gastric cancer targeted therapy unknown family history of disease M. Lazar, Daniela Adriana Ion, A. Streinu-Cercel, Anca Ioana Badarau Fahr's gastric cancer targeted therapy FD is a rare clinical neurodegenerative entity, occurring in fourth human papillomavirus dna fifth decade or elderly patients, consisting in symmetric polytopic calcifications, hpv cancer treatment one ore more of the following areas: basal ganglia, cerebral white matter, thalami, internal capsulae, cerebellum, which can lead to pyramidal, extrapyramidal, cerebellar symptoms, alteration of sensitive perception and psychiatric manifestations.
The purpose of this paper is to present the FD-diagnosis with unknown family history of disease, based on calcification pattern, symptomatology and lab tests. A three years retrospective study was gastric cancer targeted therapy on patients, aged between 20 and year-old, presenting neurological and psychiatric symptoms, which required differential diagnosis with FD.
All the patients were evaluated by CT-scans and levels of serum calcium and alkaline phosphatase were measured in cases with cerebral calcification, in order to exclude abnormal calcium-phosphorus metabolism.
Gastric cancer targeted therapy.
Cerebral and cerebellar calcification were found in cases, seven cases presenting a calcification pattern suggestive for FD and in six from the seven cases a positive diagnosis of FD was established.
Corresponding author: Mihai Lazar, MD, e-mail: mihai. The genotoxicity study of resveratrol in primary gastric adenocarcinoma cell cultures P. Mitrut, Fl. Burada, Aurelia Enescu, R. Rogoz, Madalina Manea Gastric cancer is the second most common cause of cancer-related death in the world. Some studies indicate that polyphenolic compounds and antioxidants exert a protective action against gastric cancer.
Among the polyphenolic compounds tested and proven effective against gastric cancer is resveratrol, a natural polyphenol present in red wines and various human food items. Gastric cancer targeted therapy has been shown to suppress proliferation of a wide variety of tumor cells.
