Maedica Buchar ; 11 3 :Sep. Article En MEDLINE ID: mdl Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue MALT is a low-grade malignant lymphoma that appears frequently in the stomach, but other sites can also be involved: the intestinal tract, lungs, head, neck, skin, thyroid, breasts and liver.
Recently, epidemiological evidences support the idea that there is an association between hepatitis C and B-cell non-Hodgkin lymphomas that include MALT as a subtype. Primary non-Hodgkin lymphomas confi ned only to the liver are very rare only 0.
We present the case of a male patient, age 62, known with chronic hepatitis C, previously relapser a" er a 72 week treatment with peg-interferon alfa and ribavirin that was diagnosed at three years a" er the relapse with multiple focal liver lesions. One of the tumors was surgically gastric cancer of diagnosis and the histological exam performed demonstrated an extranodal marginal zone lymphoma with small B-cell with plasmacytoid diff erentiation confi ned only to the liver.
Direct acting antiviral DAA therapy was started, but the virologic clearance was not obtained by week 10, leading to a change of DAA regimen at week The antiviral therapy was continued until week Imaging showed an increase in number and size of the focal lesions until week At week 12 chemo- and immune-therapy was started with bendamustine and rituximab. A" erwards the evolution was favorable, the patient being now in complete remission and with undetectable viral load.